Best Researcher Award

Ziyi Zhou is a postgraduate researcher in Oncology at Jiangxi Medical College, Nanchang University, whose academic work focuses on tumor microenvironment biology, exosome-mediated immune regulation, and the emerging role of microplastics in lung cancer pathogenesis. His educational and clinical training encompasses medicine, general practice, and oncology research. Through interdisciplinary investigations combining molecular oncology, environmental health sciences, and translational medicine, Zhou has contributed to understanding mechanisms of cancer progression and immune dysfunction. His research outputs include peer-reviewed publications, international conference presentations, and nationally recognized scientific communication initiatives.[1]

Abstract

This academic profile summarizes the educational background, clinical experience, research activities, and scholarly contributions of Ziyi Zhou. His work centers on molecular oncology, exosome biology, immune regulation, and environmental carcinogenesis. His published research identified a novel Aurora A-mediated exosomal signaling mechanism associated with T-lymphocyte apoptosis, while his ongoing investigations explore the presence and biological significance of microplastics in lung cancer tissues. Through conference presentations, peer-reviewed publication, and professional society participation, Zhou has demonstrated a growing contribution to contemporary cancer research and translational oncology.[1]

Keywords

Oncology; Tumor Microenvironment; Exosomes; Aurora A Kinase; T-Lymphocyte Apoptosis; Microplastics; Lung Adenocarcinoma; Environmental Carcinogenesis; Immune Regulation; Translational Medicine; NSCLC; Cancer Biology.

Introduction

Ziyi Zhou completed a Bachelor of Medicine degree from Gannan Medical University between 2013 and 2018 before undertaking standardized residency training in General Practice at the Affiliated Hospital of Jinggangshan University. Following clinical service as an attending physician, he transitioned into oncology-focused postgraduate research at Jiangxi Medical College, Nanchang University. This progression from clinical medicine to scientific investigation has enabled him to integrate patient-centered perspectives with mechanistic cancer research.[2]

Research Profile

Zhou’s primary research interests encompass tumor microenvironment dynamics, exosome-mediated signaling pathways, immune cell regulation, and environmental factors contributing to cancer development. His studies explore how cellular communication mechanisms influence disease progression and therapeutic outcomes. Recent work has also examined microplastic accumulation within pulmonary tumor tissues, contributing to a rapidly developing field investigating environmental contaminants and human health risks.[1]

• Master’s candidate in Oncology at Jiangxi Medical College, Nanchang University.
• Former attending physician in general practice.
• Member of ESMO, CACA, and CSCO.
• Presenter at ESMO Asia 2025 and national scientific meetings.
• Research focus on cancer immunology and environmental oncology.

Research Contributions

One of Zhou’s notable contributions is the identification of an Aurora A-mediated mechanism that promotes exosomal secretion of miR-644a and subsequently induces T-lymphocyte apoptosis through the NOXA/p4E-BP1/MCL-1 signaling pathway. This work contributes to a broader understanding of tumor-associated immune suppression and provides insight into molecular pathways relevant to cancer progression.[1]

In addition, he conducted pioneering investigations into microplastic occurrence within peritumoral and tumor tissues of lung adenocarcinoma. These findings have generated interest in environmental exposures as potential contributors to carcinogenesis and disease progression. His systematic review and meta-analysis evaluating concurrent versus sequential chemoradiotherapy combined with immune checkpoint inhibitors in non-small-cell lung cancer further demonstrates his engagement with evidence-based oncology research.[3]

Publications

• Zhou Z., Chen B., Zheng K., Wan D., and Kuang P. (2026). Aurora A-Mediated Exosomal Secretion of miR-644a Promotes T-Lymphocyte Apoptosis Through the NOXA/p4E-BP1/MCL-1 Pathway. Clinical and Experimental Pharmacology and Physiology, 53(6), e70132.
• Characterization and Evaluation of Microplastics in Peritumoral and Tumor Tissues of Lung Adenocarcinoma. Poster Presentation, ESMO Asia Congress 2025.
• Systematic Review and Meta-analysis of Concurrent versus Sequential Chemoradiotherapy Combined with Immune Checkpoint Inhibitors in NSCLC. National Conference Poster Presentation, 2025.

Research Impact

Although still at an early stage of his research career, Zhou’s work has demonstrated scientific relevance in both molecular and environmental oncology. His publication in a PubMed-indexed journal, participation in international conferences, and interdisciplinary approach illustrate an emerging research profile. Furthermore, his science communication activities addressing microplastics and cancer risk have contributed to public awareness and community engagement in cancer prevention topics.[1]

Award Suitability

Ziyi Zhou demonstrates several characteristics consistent with consideration for a Best Researcher Award nomination. These include original scientific contributions, interdisciplinary research engagement, publication in peer-reviewed international literature, active participation in professional societies, conference dissemination, and commitment to addressing emerging public health concerns. His combination of clinical experience and laboratory-based investigation provides a foundation for continued contributions to oncology and translational medical research.[1]

Conclusion

The academic profile of Ziyi Zhou reflects a developing researcher with expertise spanning medicine, oncology, immunology, and environmental health sciences. His work on exosome-mediated immune regulation and microplastic-associated carcinogenesis contributes to contemporary scientific discussions regarding cancer biology and disease prevention. Continued research activities and scholarly dissemination are expected to strengthen his impact within the field of oncology.

External Links

• ORCID Profile

References

1. Zhou, Z., Chen, B., Zheng, K., Wan, D., & Kuang, P. (2026). Aurora A-Mediated Exosomal Secretion of miR-644a Promotes T-Lymphocyte Apoptosis Through the NOXA/p4E-BP1/MCL-1 Pathway. Clinical and Experimental Pharmacology and Physiology, 53(6), e70132.https://doi.org/10.1111/1440-1681.70132
2. ORCID. (2026). Ziyi Zhou – ORCID Record.https://orcid.org/0009-0000-6766-3405
3. European Society for Medical Oncology (ESMO). (2025). ESMO Asia Congress Scientific Presentation Records.https://www.esmo.org